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This ascending progression of conductive connexions reaches its final term in the cerebral cortex anxiety 8 year old bupropion 150 mg trusted. It is, therefore, a corollary from every this law of increasing complexity of representation in the ascending direction, of the cortex, that is, as bearing more particularly upon the functions cortical area in the brain of bility, itself man and of the higher animals in all probaof the the seat of a manifold representation. This principle of increasing differentiation in the ascending direction enables us to explain a further fact, suggested by the results of the gross anatomy logical of the brain, but brought out with especial clearness by histo- function that examination of the conduction paths and by the phenomena of we describe in the following Chapter. This is the fact that of the functions many, perhaps most are finally integrated which in man and the higher mammals and co-ordinated in the cerebral cortex, appear in as sight the lower vertebrates to be completely centralised in the mesencephalic ganglia hearing. This accounts for the comparative insignificance of the mesencephalic region in the brain of the higher animals and of man. We answer it by saying that one, and only one such difference may probably be inferred from the anatomical and physiological relations of the conduction paths. This is the difference in direction of conduction, conof origin of the nervous processes, nected with the twofold mode which was (p. Originating way, however, the principle of different directions of conduction can hardly be looked upon as a law of universal validity. It is rather a principle of development, entirely compatible with the persistence of an undifferentiated condition in certain of the central elements. We have, as a matter of fact, found this condition to obtain in various types; of cells, in v/hich the twofold mode of origin of the conduction paths is" neither anatomically proved nor physiologically probable. And it is note- worthy that these cells always occur in situations where the functional requirements do not include a differentiation of the directions of con-. Thus, the differentiation is more or less doubtful in; many cells of the sensory system, from those of the spinal ganglia onwards there is; and there are many intercalary cells, some lying within the central organs, some displaced far outwards in peripheral sense organs, which physiologically give no ground whatever for the assumption of a definite direction of conduction, and morphologically offer no sign of a twofold mode of origin of their processes. The differentiation of the directions of conduction is, then, the result of a process of differentiation peculiar to the nerve cell, and apparently It is, connected with an especial modification of the ceU structure. It can tell us where, between what terminal stations, and (under favourable conbut it cannot ditions) in which directions the processes are conducted; 228-9] tell it is Differentiation of Directions and Central Colligation 229 us anything of the nature of the processes themselves.

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